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Sunday July 6, 2008

Target accessibility prediction and RNA duplex thermodynamics for rational siRNA design
Target accessibility prediction and rational design of antisense oligonucleotides and nucleic acid probes
Target accessibility prediction and rational design of trans-cleaving ribozymes
General features and output for statistical RNA folding
Energetic characteristics of hybridization between a structured target and a microRNA


Long, D., Lee, R., Williams, P., Chan, C.Y., Ambros, V. and Ding, Y. (2007) Potent effect of target structure on microRNA function. Nat. Struct. Mol. Biol. 14, 287-294.
[ Abstract ] [ PDF file ] [ Supplementary information ] [ Highlight by Nature 446, 587. ]
[ Faculty of 1000 Recommended ]
Chan, C.Y. and Ding, Y. (2007) Boltzmann ensemble features of RNA secondary structures: a comparative analysis of biological RNA sequences and random shuffles. J. Math. Biol. (To appear)
[ Pre-print PDF ]
Shao, Y., Wu, Y., Chan, C.Y., McDonough, K. and Ding, Y. (2006) Rational design and rapid screening of antisense oligonucleotides for prokaryotic gene modulation. Nucleic Acids Res. 34, 5660-5669.
[ Abstract ] [ PDF file ]
Ding, Y., Chan, C.Y. and Lawrence, C.E. (2006) Clustering of RNA secondary structures with application to messenger RNAs. J. Mol. Biol. 359, 554-571.
[ Abstract ] [ PDF file ] [ Related review article by Mathews, D.H. ]
Ding, Y. (2006) Statistical and Bayesian approaches to RNA secondary structure prediction. RNA 12, 323-331.
[ Abstract ] [ PDF file ]
Chan, C.Y., Lawrence, C.E. and Ding, Y. (2005) Structure clustering features on the Sfold Web server. Bioinformatics 21, 3926-3928.
[ Abstract ] [ PDF file ]
Ding, Y., Chan, C.Y. and Lawrence, C.E. (2005) RNA secondary structure prediction by centroids in a Boltzmann weighted ensemble. RNA 11, 1157-1166.
[ Abstract ] [ PDF file ] [ Supplementary information ] [ Faculty of 1000 Recommended ]
Ding, Y. and Lawrence, C.E. (2005) Rational design of siRNAs with the Sfold software. In RNA Interference: from Basic Science to Drug Development, ed. Krishnarao Appasani, Cambridge University Press. [ PDF file ]
Ding, Y., Chan, C.Y. and Lawrence, C.E. (2004) Sfold web server for statistical folding and rational design of nucleic acids. Nucleic Acids Res. 32 Web Server issue, W135-W141.
[ Abstract ] [ PDF file ]
Ding, Y. and Lawrence, C.E. (2003) A statistical sampling algorithm for RNA secondary structure prediction. Nucleic Acids Res. 31, 7280-7301.
[ Cover ] [ Abstract ] [ Article ] [ Faculty of 1000 Must Read ]
Ding, Y. (2002) Rational statistical design of antisense oligonucleotides for high throughput functional genomics and drug target validation. Statistica Sinica 12, 273-296.
[ Abstract ] [ PDF file ]
Ding, Y. and Lawrence, C.E. (2001) Statistical prediction of single-stranded regions in RNA secondary structure and application to predicting effective antisense target sites and beyond. Nucleic Acids Res. 29, 1034-1046.
[ Abstract ] [ PDF file ]
Ding, Y. and Lawrence, C.E. (1999) A Bayesian statistical algorithm for RNA secondary structure prediction. Computer & Chemistry 23, 387-400.
[ Abstract ] [ PDF file ]
[ Comments in a review by Zuker (2000) Curr Opin Struct Biol. 10, 303-310. ]


mfold/ RNAstructure Vienna RNA Package BLAST PubMed/Entrez
RNA Nucleic Acid Res. Antisense & Nucleic Acid Drug Dev. The RNA Society
Science Nature/Nat.Biotech. PNAS J. Mol. Biol.
Bioinformatics/
J. Comp. Bio.
Bayesian Bioinformatics RPI/Wadsworth BiC ISCB




S
fold 2.0
application server - page visits since April 1, 2003





Grant 5R01GM068726-04

Grant 0650991
Grant 0200970