IN THE UNITED STATES PATENT AND TRADEMARK OFFICE
| Title: | STATISTICAL ALGORITHMS FOR FOLDING AND TARGET ACCESSIBILITY PREDICTION AND DESIGN OF NUCLEIC ACIDS |
| Inventors: | Ye DING, Charles E. LAWRENCE |
| Owner: | Wadsworth Center/Health Research, Inc., New York State |
| Filing date: | January 28, 2003 (U.S. Provisional Patent Application 60/352,643, filed January 29, 2002) |
| Abstract of the disclosure |
| A method of predicting structural characteristics of a nucleic acid molecule. A method of predicting single-stranded regions in the secondary structure of a nucleic acid molecule in accordance with a probability distribution of structures based on recursively generated partition functions for the identification of accessible sites on target RNA for gene down-regulation and the rational design of antisense oligos, trans-cleaving ribozymes, siRNAs and antisense RNAs, for interaction with other RNA-targeting molecules, and for rational design of nucleic acid probes such as molecular beacons for RNA or DNA targets. |
| Law firm information |
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Office reference #: 454311-2230.1 WO William S. Frommer, Registration No. 25,506 Thomas J. Kowalski, Registration No. 32,147 Gordon M. Kessler, Registration No. 38,511 Dexter T. Chang, Registration No. 44,071 FROMMER LAWRENCE & HAUG LLP 745 Fifth Avenue New York, New York 10151 Tel. (212) 588-0800 Fax (212) 588-0500 |